David A. Karnofsky memorial lecture. Thoughts on chemical therapy

David A. Karnofsky Memorial Award Lecture

THE EXPANDING knowledge of signaling pathways regulating cell growth, cell cycle progression, and programmed cell death has led to a dramatic improvement in our understanding of the molecular events involved in cancer. This knowledge has allowed the identification of numerous targets for anticancer agents. As we move forward into an era of molecularly targeted therapeutics, it is worth reviewin...

Sir David Bruce memorial lecture 1988.

Who took the clinical out of clinical research?--Mouse versus man: seventh David A Karnofsky Memorial Lecture--1976.

When I learned in 1976 that I had been chosen as the seventh nember of the American Societvfrr Clinical Oncology to deliver the prestigious Karnofskv Lecture, I was not only honored, but inspired. I felt that it would be tn responsibility to discuss a topic that was of great importance and might have an impact on the future of clinical cancer research. The organizing committee for this Suppleme...

The 39th David A. Karnofsky Lecture: bench-to-bedside translation of targeted therapies in multiple myeloma.

Multiple myeloma (MM) is a remarkable example of rapid bench-to-bedside translation in new drug development. The proteasome inhibitor bortezomib and immunomodulatory drug lenalidomide targeted MM cells in the bone marrow (BM) microenvironment to overcome conventional drug resistance in laboratory and animal models and were rapidly translated into clinical trials demonstrating their efficacy in ...

The Stribeck memorial lecture

Stribeck’s publications ‘Kugellager für beliebige Belastungen’ and ‘Die wesentlichen Eigenschaften der Gleitund Rollenlager’ were remarkable for their time. Many of the findings were revolutionary and are still considered quite modern. The method used by Stribeck to calculate load distribution between the balls within a ball bearing is still used today, otherwise, a full finite element analysis...